N-Alkyl-N-arylmethylpiperidin-4-amines: novel dual inhibitors of serotonin and norepinephrine reuptake

J R Boot; S L Boulet; B P Clark; M J Cases-Thomas; L Delhaye; K Diker; J Fairhurst; J Findlay; P T Gallagher; J Gilmore; J R Harris; J J Masters; S N Mitchell; M Naik; R G Simmonds; S M Smith; S J Richards; G H Timms; M A Whatton; C N Wolfe; V A Wood

doi:10.1016/j.bmcl.2006.02.008

N-Alkyl-N-arylmethylpiperidin-4-amines: novel dual inhibitors of serotonin and norepinephrine reuptake

Bioorg Med Chem Lett. 2006 May 15;16(10):2714-8. doi: 10.1016/j.bmcl.2006.02.008. Epub 2006 Feb 23.

Affiliation

¹ Eli Lilly and Company, Ltd, Lilly Research Centre, Windlesham, Surrey, GU20 6PH, UK.

PMID: 16497500
DOI: 10.1016/j.bmcl.2006.02.008

Abstract

A series of N-alkyl-N-arylmethylpiperidin-4-amines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake.

MeSH terms

Norepinephrine / antagonists & inhibitors*
Piperidines / chemistry
Piperidines / pharmacology*
Selective Serotonin Reuptake Inhibitors / chemistry
Selective Serotonin Reuptake Inhibitors / pharmacology*
Structure-Activity Relationship

Substances

Piperidines
Serotonin Uptake Inhibitors
Norepinephrine